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Age-associated changes in the blood-brain barrier: comparative studies in human and mouse.

E F GoodallC WangJulie E SimpsonD J BakerD R DrewP R HeathM J SaffreyI A RomeroS B Wharton
Published in: Neuropathology and applied neurobiology (2017)
This study demonstrates BBB dysfunction in normal brain ageing, both in human and mouse cohorts.
Keyphrases
  • endothelial cells
  • induced pluripotent stem cells
  • pluripotent stem cells
  • blood brain barrier
  • oxidative stress
  • resting state
  • functional connectivity
  • cerebral ischemia
  • subarachnoid hemorrhage