ABCB1 and ERCC1 gene polymorphisms are associated with nephro- and hepatotoxicity to carboplatin/paclitaxel-based chemotherapy in patients with gynecologic cancers.

Luiz Carlos da Costa JuniorClarissa Lourenço de CastroDaniely Regina Freitas-AlvesRosane Vianna-JorgePaulo Caleb Júnior Lima Santos

Published in: European journal of clinical pharmacology (2020)

ABCB1 c.1236C>T and ERCC1 c.118C>T might serve as potential biomarkers for the risk of moderate-to-severe toxicities to carboplatin/paclitaxel chemotherapy of gynecological cancers.

Keyphrases

phase ii study
locally advanced
chemotherapy induced
dna repair
drug induced
phase iii
squamous cell carcinoma
early onset
radiation therapy
dna damage
randomized controlled trial
endometrial cancer
open label
young adults