Biological effects of selective COX-2 inhibitor NS398 on human glioblastoma cell lines.

Paola PalumboFrancesca LombardiFrancesca Rosaria AugelloIlaria GiustiVincenza DoloPietro LeocataMaria Grazia CifoneBenedetta Cinque

Published in: Cancer cell international (2020)

Despite the intrinsic diversity and individual genetic features of U87MG and T98G, comparable effects were exerted by the COX-2 inhibitor NS398 on both GBM cell lines. Overall, our findings support the crucial role of the inflammatory-associated COX-2/PGE2 system in glioma and glioma stem cell biology.

Keyphrases

stem cells
endothelial cells
dengue virus
oxidative stress
genome wide
induced pluripotent stem cells
pluripotent stem cells
copy number
gene expression