Epigenetic Regulation of Cardiomyocyte Maturation by Arginine Methyltransferase CARM1.

Tiffany A GarbuttZhenhua WangHao Fei Wang Hong MaHongmei RuanYanhan DongYifang XieLianmei TanRanan PhookanJoy StoufferVasanth Vedantham Yuchen Yang Li Qian Jiandong Liu

Published in: Circulation (2024)

This study establishes a critical and multifaceted role for CARM1 in regulating cardiomyocyte maturation and demonstrates that deregulation of CARM1-dependent cardiomyocyte maturation gene expression may contribute to human heart diseases.

Keyphrases

gene expression
angiotensin ii
endothelial cells
high glucose
dna methylation
nitric oxide
heart failure
induced pluripotent stem cells
atrial fibrillation
pluripotent stem cells