Doxorubicin Promotes Migration and Invasion of Breast Cancer Cells through the Upregulation of the RhoA/MLC Pathway.

Chien-Liang LiuMing-Jen ChenJiunn-Chang LinChi-Hsin LinWen-Chien HuangShih-Ping ChengShan-Na ChenYuan-Ching Chang

Published in: Journal of breast cancer (2019)

Doxorubicin activates the RhoA/MLC pathway and enhances breast cancer cell migration and invasion. Therefore, this pathway might be explored as a therapeutic target to suppress anthracycline-enhanced tumor progression.

Keyphrases

breast cancer cells
poor prognosis
drug delivery
cancer therapy
signaling pathway