Solvent- and Catalyst-Free Synthesis of gem -Difluorinated and Polyfluoroarylated Compounds with Nucleophilic or Electrophilic Fluorine-Containing Reaction Partners, Respectively.
Lingheng LiJinshan LiPublished in: Molecules (Basel, Switzerland) (2024)
A novel, efficient and environmentally friendly solvent-free and catalyst-free approach for the synthesis of structurally diverse gem -difluorinated and polyfluoroarylated derivatives with readily available nucleophilic and electrophilic fluorine-containing reaction partners, difluoroenoxysilane and pentafluorobenzaldehyde, is described. This neat protocol is induced by the direct hydrogen-bond interactions between fluorinated and non-fluorinated reactants without the use of heavy metal catalysts or volatile organic solvents and with no need for column chromatographic separation for most cases.
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