Respiratory infections regulated blood cells IFN-β-PD-L1 pathway in pediatric asthma.
Julia KöllePatricia HaagTytti VuorinenKiefer AlexanderManfred RauhTheodor ZimmermannNikolaos G PapadopoulosSusetta FinottoPublished in: Immunity, inflammation and disease (2020)
These data indicate that, in the presence of infection in the airways of preschool children, worse asthma is associated with induced PD-L1 mRNA expression in blood cells. Further, type I IFN, IFN-β, a cytokine that is involved in the clearance of infections, was found to be associated with a better lung function in asthmatic children. These data suggest that improving peripheral blood IFN type I expression in PBMCs in pediatric asthma could improve disease exacerbation due to suppressing PD-L1 expression in blood cells.
Keyphrases
- lung function
- chronic obstructive pulmonary disease
- induced apoptosis
- cystic fibrosis
- cell cycle arrest
- dendritic cells
- immune response
- air pollution
- peripheral blood
- signaling pathway
- poor prognosis
- endoplasmic reticulum stress
- young adults
- oxidative stress
- transcription factor
- allergic rhinitis
- machine learning
- deep learning
- high glucose
- data analysis
- respiratory tract
- extracorporeal membrane oxygenation
- diabetic rats