Optimal combination of immune checkpoint and senescence molecule predicts adverse outcomes in patients with acute myeloid leukemia.
Pei-Pei WangYuling ZhangQinghua CaiQingqin LongShiyi PanWei ZhouTingfen DengWenjian MoShunqing WangYuping ZhangCaixia WangCunte ChenPublished in: Annals of medicine (2023)
High expression of ICs and SMs was associated with poor OS of AML patients. The co-expression patterns of CD276 and BAG3/SRC might be potential biomarkers for risk stratification and designing combinational immuno-targeted therapy in AML.Key MessagesHigh expression of CD276, BAG3, and SRC was associated with poor overall survival of AML patients.The co-expression patterns of CD276 and BAG3/SRC might be potential biomarkers for risk stratification and designing combinational immuno-targeted therapy in AML.