Synthesis of 8-Hydroxygeraniol.

Francesca M IppolitiJoyann S BarberYi Tang Neil K Garg

Published in: The Journal of organic chemistry (2018)

An operationally simple protocol for the conversion of geranyl acetate to 8-hydroxygeraniol is reported. The convenient two-step procedure relies on an efficient, chemo- and regioselective SeO2-promoted oxidation, followed by straightforward deacetylation. This facile means to prepare 8-hydroxygeraniol is expected to enable biosynthetic studies pertaining to thousands of monoterpene indole alkaloids.

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