Intensive Blood Pressure Lowering and DWI Lesions in Intracerebral Hemorrhage: Exploratory Analysis of the ATACH-2 Randomized Trial.
Ashkan ShoamaneshChristy CassarlyAndrea MorottiJavier M RomeroJamary Oliveira-FilhoFrieder SchlunkMichael JesselKenneth ButcherLaura GioiaAlison AyresAnastasia VashkevichKristin SchwabMohammad Rauf AfzalRenee H MartinAdnan I QureshiSteven M GreenbergJonathan RosandJoshua N Goldsteinnull nullPublished in: Neurocritical care (2021)
Randomized assignment to intensive acute blood pressure lowering did not result in a greater frequency of diffusion-weighted imaging hyperintense lesion. Alternative mechanisms of diffusion-weighted imaging hyperintense lesion formation other than hemodynamic fluctuations need to be explored. Clinical trial registration ClinicalTrials.gov (Ref. NCT01176565; https://clinicaltrials.gov/ct2/show/NCT01176565 ).
Keyphrases
- diffusion weighted imaging
- blood pressure
- contrast enhanced
- clinical trial
- double blind
- magnetic resonance imaging
- open label
- hypertensive patients
- phase ii
- phase iii
- diffusion weighted
- computed tomography
- heart rate
- liver failure
- placebo controlled
- magnetic resonance
- respiratory failure
- aortic dissection
- blood glucose
- dual energy
- study protocol
- positron emission tomography
- image quality
- randomized controlled trial
- adipose tissue