Unprecedented 4,9-Seco-Oplopanane and Seven Drimane Sesquiterpenoids from the Chinese Liverwort Lejeunea flava (Sw.) Nees.
Ming-Zhu ZhuYi LiJin-Chuan ZhouTian WangLi-Lin QianJiao-Zhen ZhangJing-Jing HanZe-Jun XuTao ShenHong-Xiang LouPublished in: Chemistry & biodiversity (2022)
An unprecedented 4,9-seco-oplopanane (1), two undescribed drimane epimers (2 and 3), and five known drimane sesquiterpenoids (4-8) were isolated from the Chinese liverwort Lejeunea flava (Sw.) Nees. The structures of the new sesquiterpenoids were determined using nuclear magnetic resonance spectroscopy, electronic circular dichroism calculations, and single-crystal X-ray diffraction measurements. The inhibitory capacity of the new compounds against nitric oxide production in lipopolysaccharide-induced RAW 264.7 murine macrophages, along with the cytotoxicity of the new compounds against A549 and HepG-2 human cancer cell lines, were discussed.
Keyphrases
- lipopolysaccharide induced
- nitric oxide
- inflammatory response
- high resolution
- endothelial cells
- papillary thyroid
- density functional theory
- molecular dynamics
- squamous cell
- molecular dynamics simulations
- induced pluripotent stem cells
- electron microscopy
- nitric oxide synthase
- hydrogen peroxide
- pluripotent stem cells
- magnetic resonance imaging
- childhood cancer
- young adults
- magnetic resonance
- contrast enhanced