Association of Baseline and Longitudinal Changes in Frailty Burden and Risk of Heart Failure in Type 2 Diabetes - Findings from the Look AHEAD Trial.

Ambarish PandeyMuhammad Shahzeb KhanKatelyn GarciaFelicia SimpsonJudy BahnsonKershaw V PatelSumitabh SinghMuthiah VaduganathanAlain BertoniDalane KitzmanKaren C JohnsonCora E LewisMark A Espelandnull null

Published in: The journals of gerontology. Series A, Biological sciences and medical sciences (2022)

Among individuals with T2DM, higher baseline frailty and worsening frailty burden over time were independently associated with higher risk of HF, particularly HFpEF after adjustment for other confounders.

Keyphrases

type diabetes
heart failure
community dwelling
glycemic control
acute heart failure
clinical trial
study protocol
risk factors
phase iii
left ventricular
insulin resistance
cross sectional
atrial fibrillation
phase ii
skeletal muscle
metabolic syndrome
weight loss