Enantioselective β-C(sp3)-H arylation of amides via synergistic nickel and photoredox catalysis.

An enantioselective benzylic β-C(sp3)-H arylation of amides via synergistic nickel and photoredox catalysis is reported. The C-H bond is activated by a bromine-radical-mediated C-H cleavage. This mild yet straightforward protocol provides arylation products in up to 96% yield and with up to 95% ee.