A lifestyle intervention of weight loss via a low-carbohydrate diet plus walking to reduce metabolic disturbances caused by androgen deprivation therapy among prostate cancer patients: carbohydrate and prostate study 1 (CAPS1) randomized controlled trial.
Stephen J FreedlandLauren HowardJenifer AllenJordan SmithJennifer StoutWilliam AronsonBrant A InmanAndrew J ArmstrongDaniel GeorgeEric WestmanPao-Hwa LinPublished in: Prostate cancer and prostatic diseases (2019)
In an underpowered study, LCD/walking did not improve insulin sensitivity at 6 months. Given most secondary outcomes were improved at 3 months with some remaining improved at 6 months and a secondary analysis showed that LCD/walking reduced insulin resistance over the study, supporting future larger studies of LCD/walking intervention to reduce ADT-induced disturbances.
Keyphrases
- randomized controlled trial
- prostate cancer
- weight loss
- insulin resistance
- metabolic syndrome
- bariatric surgery
- physical activity
- stem cells
- adipose tissue
- systematic review
- lower limb
- radical prostatectomy
- bone marrow
- high fat diet
- body mass index
- mesenchymal stem cells
- oxidative stress
- prognostic factors
- diabetic rats
- drug induced
- meta analyses