High ACTN1 Is Associated with Poor Prognosis, and ACTN1 Silencing Suppresses Cell Proliferation and Metastasis in Oral Squamous Cell Carcinoma.

Guo-Feng XieLuo-Dan ZhaoQiang ChenDong-Xiao TangQiong-Yu Chen Hong-Fei Lu Jia-Rong CaiZheng Chen

Published in: Drug design, development and therapy (2020)

ACTN1 levels were significantly associated with the clinical stage and node metastasis, and a high ACTN1 protein level indicated poor prognosis. Moreover, ACTN1 knockdown could suppress cell proliferation and metastasis of OSCC. Our results suggested that ACTN1 may serve as a diagnostic and prognostic marker of OSCC.

Keyphrases

poor prognosis
long non coding rna
cell proliferation
cell cycle
lymph node
signaling pathway
pi k akt
protein protein
binding protein