Statistical approaches to identify subgroups in meta-analysis of individual participant data: a simulation study.

Michail BeliasMaroeska M RoversJohannes B ReitsmaThomas P A DebrayJoanna IntHout

Published in: BMC medical research methodology (2019)

Our results indicate that subgroup detection in IPD-MA requires careful modelling. Naive and centred IPD-MA performed equally well, but due to less bias of the estimates in the presence of ecological bias, we recommend the latter.

Keyphrases

systematic review
meta analyses
electronic health record
climate change
hiv infected
loop mediated isothermal amplification
big data
case control
randomized controlled trial
deep learning