Predictive Value of Minimal Residual Disease for Efficacy of Rituximab Maintenance in Mantle Cell Lymphoma: Results From the European Mantle Cell Lymphoma Elderly Trial.
Eva HosterMarie-Hélène Delfau-LarueElizabeth MacintyreLinmiao JiangStephan StilgenbauerUrsula Vehling-KaiserGilles Andre SallesCatherine ThieblemontHerve TillyStefan WirthsPierre FeugierKai HübelChristian SchmidtVincent RibragHanneke C Kluin-NelemansMartin DreylingChristiane Pottnull nullPublished in: Journal of clinical oncology : official journal of the American Society of Clinical Oncology (2023)
The results confirm the strong efficacy of R-maintenance in patients who are MRD-negative after induction. Treatment de-escalation for MRD-negative patients is discouraged by our results. More effective consolidation strategies should be explored in MRD-positive patients to improve their long-term prognosis.