No Consistent Antidepressant Effects of Deep Brain Stimulation of the Bed Nucleus of the Stria Terminalis.

Paul B FitzgeraldKate HoyKaryn E RichardsonKirsten GainsfordRebecca SegraveSally E HerringZafiris J DaskalakisRichard G Bittar

Published in: Brain sciences (2024)

The results of this study do not support the application of DBS to the BNST in patients with highly resistant depression or ongoing research utilising stimulation at this brain site. The blocked randomised study design utilising fixed stimulation parameters was poorly tolerated by the participants and does not appear suitable for assessing the efficacy of DBS at this location.

Keyphrases

deep brain stimulation
parkinson disease
obsessive compulsive disorder
clinical trial
major depressive disorder
open label
sleep quality
randomized controlled trial
multiple sclerosis
bipolar disorder