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Lipid nanoparticle: advanced drug delivery systems for promotion of angiogenesis in diabetic wounds.

Hui LiZe LinLizhi OuyangChuanlu LinRuiyin ZengGuohui LiuWenjuan Zhou
Published in: Journal of liposome research (2024)
Diabetic wound is one of the most challenge in healthcare, requiring innovative approaches to promote efficient healing. In recent years, lipid nanoparticle-based drug delivery systems have emerged as a promising strategy for enhancing diabetic wound repair by stimulating angiogenesis. These nanoparticles offer unique advantages, including improved drug stability, targeted delivery, and controlled release, making them promising in enhancing the formation of new blood vessels. In this review, we summarize the emerging advances in the utilization of lipid nanoparticles to deliver angiogenic agents and promote angiogenesis in diabetic wounds. Furthermore, we provide an in-depth exploration of key aspects, including the intricate design and fabrication of lipid nanoparticles, their underlying mechanisms of action, and a comprehensive overview of preclinical studies. Moreover, we address crucial considerations pertaining to safety and the translation of these innovative systems into clinical practice. By synthesizing and analyzing the available knowledge, our review offers valuable insights into the future prospects and challenges associated with utilizing the potential of lipid nanoparticle-based drug delivery systems for promoting robust angiogenesis in the intricate process of diabetic wound healing.
Keyphrases
  • wound healing
  • healthcare
  • fatty acid
  • clinical practice
  • type diabetes
  • current status
  • endothelial cells
  • stem cells
  • optical coherence tomography
  • climate change
  • human health
  • health information
  • adverse drug