Risk factors for metachronous colorectal cancer in Lynch syndrome patients: a registry-based observational mono-institutional study cohort.

Stefano SignoroniGuglielmo Niccolò PiozziMaria Teresa RicciAndrea ManciniAlberto MorabitoLucio BertarioMarco Vitellaro

Published in: International journal of clinical oncology (2020)

Among a high-risk population for CRC, in particular LS, an extended surgery may be considered in CRC patients with specific risk factors (MLH1 or MSH2 germline pathogenic variants, history of colorectal adenomas) to reduce the risk of mCRC development.

Keyphrases

risk factors
end stage renal disease
ejection fraction
minimally invasive
newly diagnosed
prognostic factors
coronary artery bypass
copy number
cross sectional
patient reported