Melatonin regulates the circadian rhythm to ameliorate postoperative sleep disorder and neurobehavioral abnormalities in aged mice.
Xiangyang GuoYanan SongZhengqian LiNing YangTaotao LiuDengyang HanZhuonan SunChengmei ShiYang ZhouJie ShiYajie LiuXiang-Yang GuoPublished in: CNS neuroscience & therapeutics (2023)
Melatonin receptors in SCN, circadian rhythm, and ERK/CREB signaling pathway participate in the pathophysiological processes of PSD and delirium-like behavior. Melatonin intervention could be a potential preventative approach for PSD and delirium.
Keyphrases
- signaling pathway
- pi k akt
- atrial fibrillation
- cardiac surgery
- heart rate
- randomized controlled trial
- hip fracture
- patients undergoing
- epithelial mesenchymal transition
- cell proliferation
- physical activity
- sleep quality
- risk assessment
- metabolic syndrome
- type diabetes
- high fat diet induced
- depressive symptoms
- human health
- oxidative stress
- adipose tissue
- skeletal muscle