Dexamethasone mitigates remdesivir-induced liver toxicity in human primary hepatocytes and COVID-19 patients.

Kaiyan Liu Sydney Stern Emily L Heil Linhao Li Rula Khairi Scott Heyward Hongbing Wang

Published in: Hepatology communications (2023)

Our findings obtained from in vitro cell-based experiments and patient data analysis provide evidence suggesting combination of DEX and RDV holds the potential to reduce the likelihood of RDV-induced liver injury in hospitalized COVID-19 patients.

Keyphrases

data analysis
sars cov
endothelial cells
high glucose
single cell
drug induced
liver injury
diabetic rats
case report
oxidative stress
cell therapy
low dose
induced pluripotent stem cells
high dose
pluripotent stem cells
stem cells
human health
bone marrow
oxide nanoparticles