Development and application of naturally derived, cost-effective CQDs with cancer targeting potential.
Hanaa El-BorlsyNemany Abdelhamid Nemany HanafyMaged A El-KemaryPublished in: Cell biology international (2023)
Carbon quantum dots (CQDs) derived from natural sources have obtained potential interest in biomedical imaging and therapy because of their excellent biocompatibility properties, which include water solubility, simple synthesis and low cytotoxicity. Here the cytotoxicity of ethylene-diamine doped carbon quantum dots (N-CQDs) delivered to breast cancer MCF-7 cells was investigated. Folic acid was used to raise folate recognition and increase FA-NCQD accumulation in the cells, then apoptosis was assayed using nuclear fragmentation, acridine orange labeling, fluorescence imaging, flow cytometry, and caspase 3 expression. The data show that functionalization of these CQDs, derived from a natural source, have potential application in eliminating cancer cells, as shown here for the invasive breast cancer cells, MCF-7. This nano-delivery system provides a novel target therapy possibility therapeutic approach for cancer cells.
Keyphrases
- quantum dots
- breast cancer cells
- cell cycle arrest
- induced apoptosis
- fluorescence imaging
- cell death
- flow cytometry
- endoplasmic reticulum stress
- oxidative stress
- photodynamic therapy
- sensitive detection
- poor prognosis
- human health
- high resolution
- pi k akt
- papillary thyroid
- risk assessment
- stem cells
- drinking water
- long non coding rna
- metal organic framework
- energy transfer
- deep learning
- replacement therapy
- high speed
- data analysis