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Metformin Is Associated With Higher Relative Abundance of Mucin-Degrading Akkermansia muciniphila and Several Short-Chain Fatty Acid-Producing Microbiota in the Gut.

Jacobo de la Cuesta-ZuluagaNoel T MuellerVanessa Corrales-AgudeloEliana P Velásquez-MejíaJenny A CarmonaJosé M AbadJuan S Escobar
Published in: Diabetes care (2016)
Our results support the hypothesis that metformin shifts gut microbiota composition through the enrichment of mucin-degrading A. muciniphila as well as several SCFA-producing microbiota. Future studies are needed to determine if these shifts mediate metformin's glycemic and anti-inflammatory properties.
Keyphrases
  • fatty acid
  • anti inflammatory
  • type diabetes
  • current status
  • adipose tissue
  • skeletal muscle
  • weight loss
  • microbial community
  • glycemic control
  • insulin resistance