Login / Signup

Effects of the discontinuation of antihypertensive treatment on neuropsychiatric symptoms and quality of life in nursing home residents with dementia (DANTON): a multicentre, open-label, blinded-outcome, randomised controlled trial.

Jonathan M K BogaertsJacobijn GusseklooBianca E M de Jong-SchmitSaskia Le CessieSimon Pieter MooijaartRoos C van der MastWilco P AchterbergRosalinde K E Poortvliet
Published in: Age and ageing (2024)
Halfway through this study, a non-significant increased SAE risk associated with discontinuing antihypertensive treatment was observed, and an associated interim analysis showed that significant worthwhile health gain for discontinuation of antihypertensive treatment was unlikely. This unbeneficial benefit-harm balance shows that discontinuation of antihypertensive treatment in this context does not appear to be either safe or beneficial enough to be recommended in older adults with dementia.
Keyphrases