Nontypeable Haemophilus influenzae infection of pulmonary macrophages drives neutrophilic inflammation in severe asthma.

Jodie Ackland Clair BarberAshley HeinsonAdnan AzimDavid W ClearyMyron ChristodoulidesRamesh J KurukulaaratchyPeter HowarthTom M A WilkinsonKarl J Staplesnull null

Published in: Allergy (2022)

NTHi persistence with pulmonary macrophages may contribute to chronic airway inflammation and T17 responses in severe asthma, which can lead to decreased lung function and reduced steroid responsiveness. Identifying therapeutic strategies to reduce the burden of NTHi in asthma could improve patient outcomes.

Keyphrases

lung function
chronic obstructive pulmonary disease
pulmonary hypertension
cystic fibrosis
air pollution
oxidative stress
risk factors