Karl J Staples (K J Staples)

Loop profile ORCID

Publication Activity (10 Years)

Years Active: 2016-2022
Publications (10 Years): 24

Top Venues

American journal of respiratory and critical care medicine

Thorax

American journal of respiratory cell and molecular biology

ERJ open research

University of Southampton

Imperial College London (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

University of Southampton Mar 01 2018

United Kingdom

Associate Professor in Translational Medicine :: Clinical and Experimental Sciences

University of Southampton Jan 01 2016 - Feb 28 2018

United Kingdom

Lecturer in Translational Medicine :: Clinical & Experimental Sciences

University of Southampton Jan 01 2010 - Dec 31 2015

United Kingdom

Senior Research Fellow :: Clinical & Experimental Sciences

University of Southampton Sep 01 2006 - Dec 31 2009

United Kingdom

Postdoctoral Research Fellow :: Infection, Inflammation & Immunity

University of Leicester Sep 01 2003 - Aug 31 2006

United Kingdom

Postdoctoral Research Associate :: Infection, Immunity & Inflammation

Education History

Imperial College London Nov 01 1997 - Jun 01 2001

United Kingdom

PHD :: National Heart & Lung Institute

Publications

Jodie Ackland, Clair Barber, Ashley Heinson, Adnan Azim, David W Cleary, Myron Christodoulides, Ramesh J Kurukulaaratchy, Peter Howarth, Tom M A Wilkinson, Karl J Staples, null null
Nontypeable Haemophilus influenzae infection of pulmonary macrophages drives neutrophilic inflammation in severe asthma. Allergy 77 (10) (2022)
María Victoria Humbert, Cosma Mirella Spalluto, Joseph Bell, Cornelia Blume, Franco Conforti, Elizabeth R Davies, Lareb S N Dean, Paul Elkington, Hans Michael Haitchi, Claire Jackson, Mark G Jones, Matthew Loxham, Jane S A Lucas, Hywel Morgan, Marta Polak, Karl J Staples, Emily Jane Swindle, Liku Tezera, Alastair Watson, Tom M A Wilkinson
Towards an artificial human lung: modelling organ-like complexity to aid mechanistic understanding. The European respiratory journal (2022)
Ventzislava A Hristova, Alastair Watson, Raghothama Chaerkady, Matthew S Glover, Jodie Ackland, Bastian Angerman, Graham Belfield, Maria G Belvisi, Hannah Burke, Doriana Cellura, Howard W Clark, Damla Etal, Anna Freeman, Ashley I Heinson, Sonja Hess, Michael Hühn, Emily Hall, Alex Mackay, Jens Madsen, Christopher McCrae, Daniel Muthas, Steven Novick, Kristoffer Ostridge, Lisa Öberg, Adam Platt, Anthony D Postle, C Mirella Spalluto, Outi Vaarala, Junmin Wang, Karl J Staples, Tom M A Wilkinson, null null
Multiomics links global surfactant dysregulation with airflow obstruction and emphysema in COPD. ERJ open research 9 (3) (2022)
Paul Skipp, Alistair Bailey, Karl J Staples, Tom Wilkinson, Tim Elliott, Paul Skipp
Immunopeptidomic analysis of influenza A virus infected human tissues identifies internal proteins as a rich source of HLA ligands. PLoS pathogens 18 (1) (2022)
Karl J Staples
Breaching the Defences? MAIT, Smoking and COPD. American journal of respiratory cell and molecular biology (2022)
Grace E Cooper, Jemma Mayall, Chantal Donovan, Tatt J Haw, Kurtis F Budden, Nicole G Hansbro, Evy E Blomme, Tania Maes, Chia Wei Kong, Jay C Horvat, Salim I Khakoo, Tom M A Wilkinson, Philip M Hansbro, Karl J Staples
Anti-Viral Responses of Tissue-Resident CD49a+ Lung NK Cells Are Dysregulated in COPD. American journal of respiratory and critical care medicine (2022)
Clair Barber, Laurie Lau, Jonathan A Ward, Thomas Daniels, Alastair Watson, Karl J Staples, Tom M A Wilkinson, Peter H Howarth
Sputum processing by mechanical dissociation: A rapid alternative to traditional sputum assessment approaches. The clinical respiratory journal 15 (7) (2021)
Karl J Staples
Making a bad relationship good. Nature microbiology 4 (8) (2020)
Alastair Watson, C Mirella Spalluto, Christopher McCrae, Doriana Cellura, Hannah Burke, Danen Cunoosamy, Anna Freeman, Alex Hicks, Michael Hühn, Kristoffer K Ostridge, Karl J Staples, Outi Vaarala, Tom Wilkinson
Dynamics of IFN-β Responses during Respiratory Viral Infection. Insights for Therapeutic Strategies. American journal of respiratory and critical care medicine 201 (1) (2020)
Thomas Naessens, Yannick Morias, Eva Hamrud, Ulf Gehrmann, Ramachandramouli Budida, Johan Mattsson, Tina Baker, Gabriel Skogberg, Elisabeth Israelsson, Kristofer Thörn, Martijn J Schuijs, Bastian Angermann, Faye Melville, Karl J Staples, Danen M Cunoosamy, Bart N Lambrecht
Human Lung Conventional Dendritic Cells Orchestrate Lymphoid Neogenesis during Chronic Obstructive Pulmonary Disease. American journal of respiratory and critical care medicine 202 (4) (2020)
Anna T Freeman, Karl J Staples, Tom M A Wilkinson
Defining a role for exercise training in the management of asthma. European respiratory review : an official journal of the European Respiratory Society 29 (156) (2020)
Karl J Staples, N P Williams, O Bonduelle, A J Hutton, D Cellura, A C Marriott, B Combadière, T M A Wilkinson
Acquired immune responses to the seasonal trivalent influenza vaccination in COPD. Clinical and experimental immunology 198 (1) (2019)
Tom M A Wilkinson, Emmanuel Aris, Simon C Bourne, Stuart C Clarke, Mathieu Peeters, Thierry G Pascal, Laura Taddei, Andrew C Tuck, Viktoriya L Kim, Kristoffer K Ostridge, Karl J Staples, Nicholas P Williams, Anthony P Williams, Stephen A Wootton, Jeanne-Marie Devaster
Drivers of year-to-year variation in exacerbation frequency of COPD: analysis of the AERIS cohort. ERJ open research 5 (1) (2019)
David Mayhew, Nathalie Devos, Christophe Lambert, James R Brown, Stuart C Clarke, Viktoriya L Kim, Michal Magid-Slav, Bruce E Miller, Kristoffer K Ostridge, Ruchi Patel, Ganesh Sathe, Daniel F Simola, Karl J Staples, Ruby Sung, Ruth Tal-Singer, Andrew C Tuck, Stephanie Van Horn, Vincent Weynants, Nicholas P Williams, Jeanne-Marie Devaster, Tom M A Wilkinson, null null
Longitudinal profiling of the lung microbiome in the AERIS study demonstrates repeatability of bacterial and eosinophilic COPD exacerbations. Thorax 73 (5) (2018)
Karl J Staples
Macrophages and neutrophils: dynamic duo or partners in crime? Thorax 73 (6) (2018)
Akul Singhania, Joshua C Wallington, Caroline G Smith, Daniel Horowitz, Karl J Staples, Peter H Howarth, Stephan D Gadola, Ratko Djukanović, Christopher H Woelk, Timothy Stopford Christopher Hinks
Multitissue Transcriptomics Delineates the Diversity of Airway T Cell Functions in Asthma. American journal of respiratory cell and molecular biology 58 (2) (2018)
Timothy S C Hinks, Joshua C Wallington, Anthony P Williams, Ratko Djukanović, Karl J Staples, Tom M A Wilkinson
Steroid-induced Deficiency of Mucosal-associated Invariant T Cells in the Chronic Obstructive Pulmonary Disease Lung. Implications for Nontypeable Haemophilus influenzae Infection. American journal of respiratory and critical care medicine 194 (10) (2017)
Tom M A Wilkinson, Emmanuel Aris, Simon Bourne, Stuart C Clarke, Mathieu Peeters, Thierry G Pascal, Sonia Schoonbroodt, Andrew C Tuck, Viktoriya Kim, Kristoffer K Ostridge, Karl J Staples, Nicholas Williams, Anthony Williams, Stephen Wootton, Jeanne-Marie Devaster, null null
A prospective, observational cohort study of the seasonal dynamics of airway pathogens in the aetiology of exacerbations in COPD. Thorax 72 (10) (2017)
Karl J Staples, Tom M A Wilkinson
Reply: The PD-1-PD-L1 Axis in Chronic Obstructive Pulmonary Disease. American journal of respiratory and critical care medicine 194 (5) (2017)
C Mirella Spalluto, Akul Singhania, Doriana Cellura, Christopher H Woelk, Tilman Sanchez-Elsner, Karl J Staples, Tom M A Wilkinson
IFN-γ Influences Epithelial Antiviral Responses via Histone Methylation of the RIG-I Promoter. American journal of respiratory cell and molecular biology 57 (4) (2017)
Andrew J Hutton, Marta E Polak, C Mirella Spalluto, Joshua C Wallington, Chris Pickard, Karl J Staples, Jane A Warner, Tom M A Wilkinson
Human Lung Fibroblasts Present Bacterial Antigens to Autologous Lung Th Cells. Journal of immunology (Baltimore, Md. : 1950) 198 (1) (2016)
Karl J Staples, Stephen Taylor, Steve Thomas, Stephanie Leung, Karen Cox, Thierry G Pascal, Kristoffer Ostridge, Lindsay Welch, Andrew C Tuck, Stuart C Clarke, Andrew Gorringe, Tom M A Wilkinson
Relationships between Mucosal Antibodies, Non-Typeable Haemophilus influenzae (NTHi) Infection and Airway Inflammation in COPD. PloS one 11 (11) (2016)
Karl J Staples
Lung macrophages: old hands required rather than new blood? Thorax 71 (11) (2016)
Grace E Cooper, Zoe C Pounce, Joshua C Wallington, Leidy Y Bastidas-Legarda, Ben Nicholas, Chiamaka Chidomere, Emily C Robinson, Kirstin Martin, Anna S Tocheva, Myron Christodoulides, Ratko Djukanovic, Tom M A Wilkinson, Karl J Staples
Viral Inhibition of Bacterial Phagocytosis by Human Macrophages: Redundant Role of CD36. PloS one 11 (10) (2016)

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Publication Activity (10 Years)

Top Topics

Top Venues

Karl J Staples (K J Staples)