Functional Testing to Characterize and Stratify PI3K Inhibitor Responses in Chronic Lymphocytic Leukemia.

Yanping Yin Paschalis Athanasiadis Linda Karlsen Aleksandra Urban Haifeng Xu Ishwarya Murali Stacey M Fernandes Alberto J Arribas Abdul K Hilli Kjetil Taskén Francesco Bertoni Anthony R Mato Emmanuel Normant Jennifer R Brown Geir Erland Tjønnfjord Tero Aittokallio Sigrid S Skånland

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2022)

Our findings suggest novel treatment vulnerabilities in idelalisib-refractory/intolerant CLL, and indicate that ex vivo functional profiling may stratify PI3Ki responders.

Keyphrases

chronic lymphocytic leukemia
single cell
squamous cell carcinoma
replacement therapy
locally advanced