Impact of APOL1 polymorphism and IL-1β priming in the entry and persistence of HIV-1 in human podocytes.
Joanna MikulakFerdinando OrioloFederica PortalePaolo TentorioXiqian LanMoin A SaleemKarl SkoreckiPravin C SinghalDomenico MavilioPublished in: Retrovirology (2016)
Our findings indicate that the presence of risk Vs of APOL1 is permissive of HIV-1 persistence in human podocytes in synergy with IL-1β, a cytokine that characterizes the inflammatory milieu of acute and chronic phases of HIV-1 infection. The elucidation of these molecular mechanisms explains, at least in part, the higher frequency of HIVAN in populations carrying the risk polymorphic genetic variant of APOL1 gene.
Keyphrases
- antiretroviral therapy
- endothelial cells
- hiv infected
- hiv positive
- human immunodeficiency virus
- hepatitis c virus
- hiv aids
- high glucose
- hiv testing
- induced pluripotent stem cells
- genome wide
- copy number
- pluripotent stem cells
- liver failure
- oxidative stress
- gene expression
- diabetic nephropathy
- drug induced
- hepatitis b virus
- transcription factor
- dna methylation
- genome wide identification