Differences in the Expression of KIR, ILT Inhibitory Receptors, and VEGF Production in the Induced Decidual NK Cell Cultures of Fertile and RPL Women.

Monika Kniotek Aleksander Roszczyk Michał Zych Monika Szafarowska Małgorzata Maria Jerzak

Published in: BioMed research international (2021)

A combination of hypoxia, IL-15, and AZA promotes the conversion of pbNK into idNK cells CD56+CD16--expressing KIR receptors and produces VEGF. Alterations in KIR2DL1 and ILT-2 expression as well as impaired VEGF production were associated with RPL. SC affects NKG2A expression on RPL idNK cells. SC had no effect on VEGF release or idNK cell apoptosis.

Keyphrases

poor prognosis
endothelial cells
vascular endothelial growth factor
induced apoptosis
nk cells
cell cycle arrest
binding protein
oxidative stress
endoplasmic reticulum stress
cell death
adipose tissue
skeletal muscle