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Framework for the synthesis of non-randomised studies and randomised controlled trials: a guidance on conducting a systematic review and meta-analysis for healthcare decision making.

Grammati SarriElisabetta PatornoHongbo YuanJianfei Jeff GuoDimitri BennettXuerong WenAndrew R ZulloJoan LargentMary PanaccioMugdha GokhaleDaniela Claudia MogaM Sanni AliThomas P A Debray
Published in: BMJ evidence-based medicine (2020)
Our framework augments existing guidance on assessing the quality of NRS and their compatibility with RCTs for evidence synthesis, while also highlighting potential challenges in implementing it. This manuscript received endorsement from the International Society for Pharmacoepidemiology.
Keyphrases
  • healthcare
  • decision making
  • clinical trial
  • quality improvement
  • open label
  • study protocol
  • double blind
  • randomized controlled trial
  • placebo controlled
  • case control
  • risk assessment