High-dose saccharin supplementation does not induce gut microbiota changes or glucose intolerance in healthy humans and mice.

Joan SerranoKathleen R SmithAudra L CrouchVandana SharmaFanchao YiVeronika VargovaTraci E LaMoiaLydia M DupontVanida SernaFenfen TangLaisa Gomes-DiasJoshua J BlakesleeEmmanuel HatzakisScott N PetersonMatthew AndersonRichard E PratleyGeorge A Kyriazis

Published in: Microbiome (2021)

Trial registration number NCT03032640 , registered on January 26, 2017. Video abstract.

Keyphrases

high dose
low dose
phase iii
study protocol
stem cell transplantation
high fat diet induced
phase ii
clinical trial
blood glucose
randomized controlled trial
open label
wild type
adipose tissue
insulin resistance
metabolic syndrome
double blind