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Cholangiocarcinoma progression depends on the uptake and metabolization of extracellular lipids.

Mikel Ruiz de GaunaFrancesca BiancanielloFrancisco González-RomeroPedro M RodriguesAinhoa LapitzBeatriz Gómez-SantosPaula OlaizolaSabina Di MatteoIgor AurrekoetxeaIbone LabianoAne Nieva-ZuluagaAsier Benito-VicenteMaría J PerugorriaMaider Apodaka-BiguriNuno A PaivaDiego Sáenz de UrturiXabier BuquéIgotz DelgadoCésar MartínMikel AzkargortaFelix ElortzaDiego F CalvisiJesper B AndersenDomenico AlvaroVincenzo CardinaleLuis BujandaJesús M BanalesPatricia Aspichueta
Published in: Hepatology (Baltimore, Md.) (2022)
Highly proliferative human CCA cells rely on lipid and lipoprotein uptake to fuel FA catabolism, suggesting that inhibition of FAO and/or lipid uptake could represent a therapeutic strategy for this CCA subclass.
Keyphrases
  • fatty acid
  • induced apoptosis
  • endothelial cells
  • cell cycle arrest
  • induced pluripotent stem cells
  • cell death
  • cell proliferation