Cholangiocarcinoma progression depends on the uptake and metabolization of extracellular lipids.
Mikel Ruiz de GaunaFrancesca BiancanielloFrancisco González-RomeroPedro M RodriguesAinhoa LapitzBeatriz Gómez-SantosPaula OlaizolaSabina Di MatteoIgor AurrekoetxeaIbone LabianoAne Nieva-ZuluagaAsier Benito-VicenteMaría J PerugorriaMaider Apodaka-BiguriNuno A PaivaDiego Sáenz de UrturiXabier BuquéIgotz DelgadoCésar MartínMikel AzkargortaFelix ElortzaDiego F CalvisiJesper B AndersenDomenico AlvaroVincenzo CardinaleLuis BujandaJesús M BanalesPatricia AspichuetaPublished in: Hepatology (Baltimore, Md.) (2022)
Highly proliferative human CCA cells rely on lipid and lipoprotein uptake to fuel FA catabolism, suggesting that inhibition of FAO and/or lipid uptake could represent a therapeutic strategy for this CCA subclass.