Severe chronic kidney disease environment reduced calcium-sensing receptor expression in parathyroid glands of adenine-induced rats even without high phosphorus diet.
Taketo UchiyamaIchiro OhkidoAkio NakashimaYatsumu SaitoMasataka OkabeTakashi YokooPublished in: BMC nephrology (2020)
Our data suggest that the cause of the decreased PTG CaSR expression is the reduction in VDR and Gcm2 expression; Gcm2 may play a role in the onset and progression of SHPT.