Probiotics mixture reinforces barrier function to ameliorate necrotizing enterocolitis by regulating PXR-JNK pathway.

Xiuhao ZhaoJin ZhouWenhua LiangQingfeng ShengLi LuTong ChenJianglong ChenKezhe TanZhibao Lv

Published in: Cell & bioscience (2021)

Our study confirmed that probiotics could ameliorate intestinal lesions by enhancing the function of the mucosal barrier. Specifically, probiotics may target PXR, which may subsequently enhance the expression of tight junction components by inhibiting the phosphorylation of JNK and enhance the function of the barrier.

Keyphrases

signaling pathway
cell death
poor prognosis
induced apoptosis
blood brain barrier
binding protein
ulcerative colitis