Login / Signup

Multiple interactions between melatonin and non-coding RNAs in cancer biology.

Masomeh MalekiNafiseh KhelghatiForough AlemiSimin YounesiZatollah AsemiRozita AbolhasanMahtab BazdarHossein Samadi-KafilBahman Yousefi
Published in: Chemical biology & drug design (2021)
The melatonin hormone secreted by the pineal gland is involved in physiological functions such as growth and maturation, circadian cycles, and biological activities including antioxidants, anti-tumor, and anti-ischemia. Melatonin not only interacts with proteins but also has functional effects on regulatory RNAs such as long non-coding RNAs (lncRNAs) and microRNAs (miRNAs). In this study, we overview various physiological and pathological conditions affecting melatonin through lncRNA and miRNA. The information compiled herein will serve as a solid foundation to formulate ideas for future mechanistic studies on melatonin. It will also provide a chance to more clarify the emerging functions of the non-coding transcriptome.
Keyphrases
  • long non coding rna
  • poor prognosis
  • gene expression
  • squamous cell carcinoma
  • papillary thyroid
  • dna methylation
  • genome wide
  • rna seq
  • young adults
  • social media
  • genome wide identification