Multiple interactions between melatonin and non-coding RNAs in cancer biology.
Masomeh MalekiNafiseh KhelghatiForough AlemiSimin YounesiZatollah AsemiRozita AbolhasanMahtab BazdarHossein Samadi-KafilBahman YousefiPublished in: Chemical biology & drug design (2021)
The melatonin hormone secreted by the pineal gland is involved in physiological functions such as growth and maturation, circadian cycles, and biological activities including antioxidants, anti-tumor, and anti-ischemia. Melatonin not only interacts with proteins but also has functional effects on regulatory RNAs such as long non-coding RNAs (lncRNAs) and microRNAs (miRNAs). In this study, we overview various physiological and pathological conditions affecting melatonin through lncRNA and miRNA. The information compiled herein will serve as a solid foundation to formulate ideas for future mechanistic studies on melatonin. It will also provide a chance to more clarify the emerging functions of the non-coding transcriptome.