Effects of immunomodulation in classic infantile Pompe patients with high antibody titers.

E PoelmanM Hoogeveen-WesterveldJ M P van den HoutR G M BrediusA C LankesterG J A DriessenS S M KamphuisW W M PijnappelAns T van der Ploeg

Published in: Orphanet journal of rare diseases (2019)

To some extent, the immunomodulation protocol used in our study reduced antibody titers, but it did not eliminate them. Overall, there have been few reports on secondary immunomodulation, and various protocols have been applied. Future research should seek to identify the most successful immunomodulation protocol in patients with high sustained titers.

Keyphrases

randomized controlled trial
late onset
emergency department
current status
replacement therapy
early onset