Invasive growth associated with cold-inducible RNA-binding protein expression drives recurrence of surgically resected brain metastases.
Matthew DanknerMaxime CaronTariq Al-SaadiWenQing YuVéronique OuelletRima EzzeddineSarah M MaritanMatthew G AnnisPhuong Uyen LeJavad NadafNoah S NeubarthPaul SavageDongmei ZuoCharles P CouturierJean MonlongHaig DjambazianHuda AltoukhiGuillaume BourqueJiannis RagoussisRoberto J DiazMorag ParkMarie-Christine GuiotStephanie LamKevin PetreccaPeter M SiegelPublished in: Neuro-oncology (2021)
These data demonstrate peritumoral invasion as a driver of treatment failure in BrM that is functionally mediated by CIRBP. These findings improve our understanding of the biology underlying postoperative treatment failure and lay the groundwork for rational clinical trial development based upon invasion pattern in surgically resected BrM.