The expression of Notch signaling pathway components was upregulated in EAT mice, but blockade of the Notch signaling pathway alleviated the degree of thyroiditis, decreased the Th17 cell proportions, and downregulated the IL-17A effector cytokine both in vivo and in vitro. These findings suggested that the Notch signaling pathway may be involved in the pathogenesis of thyroid autoimmune injury in EAT mice by promoting the differentiation of Th17 cells.
Keyphrases
- signaling pathway
- induced apoptosis
- pi k akt
- cell proliferation
- epithelial mesenchymal transition
- high fat diet induced
- multiple sclerosis
- cell cycle arrest
- endoplasmic reticulum stress
- single cell
- poor prognosis
- drug induced
- oxidative stress
- mesenchymal stem cells
- stem cells
- metabolic syndrome
- insulin resistance
- immune response
- cell therapy
- binding protein