Cooperative treatment effectiveness of ATR and HSP90 inhibition in Ewing's sarcoma cells.

Christian MarxMarc U SchaarschmidtJoanna KirkpatrickLisa Marx-BlümelMelisa HalilovicMartin WestermannDoerte HoelzerFelix B MeyerYibo GengKatrin BuderHauke M SchadwinkelKanstantsin SiniukSabine BeckerRené ThierbachJames F BeckJürgen SonnemannZhao-Qi Wang

Published in: Cell & bioscience (2021)

Our study reveals that HSP90 and ATR inhibitor combination treatment may be an effective therapeutic approach for Ewing's sarcoma irrespective of the p53 status.

Keyphrases

randomized controlled trial
induced apoptosis
heat stress
heat shock
cell cycle arrest
endoplasmic reticulum stress
replacement therapy
dna repair