A prospective study of the adaptive changes in the gut microbiome during standard-of-care chemoradiotherapy for gynecologic cancers.
Molly B El AlamTravis T SimsRamez KouzyGreyson W G BiegertJoseph A B I JaoudeTatiana V KarpinetsKyoko Yoshida-CourtXiaogang WuAndrea Y Delgado-MedranoMelissa P MezzariNadim J AjamiTravis SolleyMustapha Ahmed-KaddarLilie L LinLois RamondettaAmir JazaeriAnuja JhingranPatricia J EifelKathleen M SchmelerJennifer WargoAnn H KloppLauren E ColbertPublished in: PloS one (2021)
After CRT, the diversity of the gut microbiomes in this population tended to return to baseline levels by the 12 week follow-up period, but structure and composition remained significantly altered. These changes should be considered when designing studies to analyze the gut microbiome in patients who receive pelvic CRT for gynecologic cancers.
Keyphrases
- rectal cancer
- cardiac resynchronization therapy
- endometrial cancer
- healthcare
- locally advanced
- palliative care
- quality improvement
- heart failure
- pain management
- case control
- randomized controlled trial
- squamous cell carcinoma
- clinical trial
- affordable care act
- atrial fibrillation
- childhood cancer
- study protocol
- double blind