A systems pharmacology-based approach to identify novel Kv1.3 channel-dependent mechanisms in microglial activation.

Srikant RangarajuSyed Ali RazaAndrea PennatiQiudong DengEric B DammerDuc DuongMichael W PenningtonMalu G TanseyJames J LahRanjita BetarbetNicholas T SeyfriedAllan I Levey

Published in: Journal of neuroinflammation (2017)

We have unraveled novel molecular and functional roles for Kv1.3 channels in pro-inflammatory microglial activation, including a Kv1.3 channel-regulated pathway that facilitates MHCI expression and MHCI-dependent antigen presentation by microglia to CD8+ T cells. We also provide evidence for neuro-immunomodulation by systemically administered ShK peptides. Our results further strengthen the therapeutic candidacy of microglial Kv1.3 channels in neurologic diseases.

Keyphrases

inflammatory response
neuropathic pain
image quality
lipopolysaccharide induced
lps induced
dual energy
poor prognosis
computed tomography
spinal cord
transcription factor