Targeting a Radiosensitizing Antibody-Drug Conjugate to a Radiation-Inducible Antigen.
Calvin D LewisAbhay K SinghFong-Fu HsuDinesh ThotalaDennis E HallahanVaishali KapoorPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2022)
Targeting radiation-inducible TIP1 with a radiosensitizing ADC is a promising strategy to enhance the therapeutic efficacy of NSCLC. This novel approach of targeting with ADCs to radiation-inducible antigens will lead to clinical trials in lung cancer patients treated with radiotherapy.