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Single-Dose Pharmacokinetics of Milvexian in Participants with Mild or Moderate Hepatic Impairment Compared with Healthy Participants.

Vidya PereraGrigor AbelianDanshi LiZhaoqing WangLiping ZhangSusan LubinWei ChenAkintunde BelloBindu Murthy
Published in: Clinical pharmacokinetics (2022)
Milvexian was well tolerated in participants with normal, mildly impaired, and moderately impaired hepatic function. Observed pharmacokinetic changes suggest it is unlikely that dose adjustments will be necessary in patients with mild or moderate hepatic impairment. Clinical Trial RegistrationClinicaltrials.gov identifier: NCT02982707.
Keyphrases
  • clinical trial
  • high intensity
  • study protocol
  • randomized controlled trial
  • open label
  • phase ii
  • double blind