A dysfunctional T cell gene signature for predicting non-response to PD-1 blockade in non-small cell lung cancer that is suitable for routine clinical diagnostics.

Karlijn Hummelink Renaud Tissier Linda J W Bosch Oscar Krijgsman Michel van den Heuvel Willemijn S M E Theelen Diane Damotte Francois Goldwasser Karen Leroy Egbert F Smit Gerrit A Meijer Daniela S Thommen Kim Monkhorst

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2023)

The PD-1T mRNA signature showed a similar high sensitivity and high NPV as the digital IHC quantification of PD-1T TILs. This provides a straightforward approach allowing for easy implementation in a routine diagnostic clinical setting.

Keyphrases

clinical practice
healthcare
primary care
gene expression
transcription factor
genome wide identification