Daniela S Thommen (Daniela Thommen)

Publication Activity (10 Years)

Years Active: 2018-2024
Publications (10 Years): 35

Top Topics

Small Cell Lung Cancer

Immune Response

Top Venues

Cancer discovery

Nature communications

This page only lists publications with an associated author ORCID identifier.

Publications

Karlijn Hummelink, Vincent van den Noort, Mirte Muller, Robert D Schouten, Michel van den Heuvel, Daniela S Thommen, Egbert F Smit, Gerrit A Meijer, Kim Monkhorst
Head-to-head comparison of composite and individual biomarkers to predict clinical benefit to PD-1 blockade in non-small cell lung cancer. PloS one 19 (7) (2024)
Paulien Kaptein, Nadine Slingerland, Christina Metoikidou, Felix Prinz, Simone Brokamp, Mercedes Machuca-Ostos, Guido de Roo, Ton N M Schumacher, Yik A Yeung, Kelly D Moynihan, Ivana M Djuretic, Daniela S Thommen
CD8-Targeted IL2 Unleashes Tumor-Specific Immunity in Human Cancer Tissue by Reviving the Dysfunctional T-cell Pool. Cancer discovery 14 (7) (2024)
Karlijn Hummelink, Vincent van den Noort, Mirte Muller, Robert D Schouten, Michel van den Heuvel, Daniela S Thommen, Egbert F Smit, Gerrit A Meijer, Kim Monkhorst
Head-to-head comparison of composite and individual biomarkers to predict clinical benefit to PD-1 blockade in non-small cell lung cancer. PloS one 19 (7) (2024)
Karlijn Hummelink, Vincent van den Noort, Mirte Muller, Robert D Schouten, Michel van den Heuvel, Daniela S Thommen, Egbert F Smit, Gerrit A Meijer, Kim Monkhorst
Head-to-head comparison of composite and individual biomarkers to predict clinical benefit to PD-1 blockade in non-small cell lung cancer. PloS one 19 (7) (2024)
Tessa S Groen-van Schooten, Rosalia Franco Fernandez, Nicole C T van Grieken, Emma N Bos, Jens Seidel, Job Saris, Carolina Martínez-Ciarpaglini, Tania C Fleitas, Daniela S Thommen, Tanja D de Gruijl, Joep Grootjans, Sarah Derks
Mapping the complexity and diversity of tertiary lymphoid structures in primary and peritoneal metastatic gastric cancer. Journal for immunotherapy of cancer 12 (7) (2024)
Paulien Kaptein, Nadine Slingerland, Christina Metoikidou, Felix Prinz, Simone Brokamp, Mercedes Machuca-Ostos, Guido de Roo, Ton N M Schumacher, Yik A Yeung, Kelly D Moynihan, Ivana M Djuretic, Daniela S Thommen
CD8-Targeted IL2 Unleashes Tumor-Specific Immunity in Human Cancer Tissue by Reviving the Dysfunctional T-cell Pool. Cancer discovery 14 (7) (2024)
Tessa S Groen-van Schooten, Rosalia Franco Fernandez, Nicole C T van Grieken, Emma N Bos, Jens Seidel, Job Saris, Carolina Martínez-Ciarpaglini, Tania C Fleitas, Daniela S Thommen, Tanja D de Gruijl, Joep Grootjans, Sarah Derks
Mapping the complexity and diversity of tertiary lymphoid structures in primary and peritoneal metastatic gastric cancer. Journal for immunotherapy of cancer 12 (7) (2024)
Paulien Kaptein, Nadine Slingerland, Christina Metoikidou, Felix Prinz, Simone Brokamp, Mercedes Machuca-Ostos, Guido de Roo, Ton N M Schumacher, Yik A Yeung, Kelly D Moynihan, Ivana M Djuretic, Daniela S Thommen
CD8-targeted IL2 unleashes tumor-specific immunity in human cancer tissue by reviving the dysfunctional T cell pool. Cancer discovery (2024)
Paulien Kaptein, Nadine Slingerland, Christina Metoikidou, Felix Prinz, Simone Brokamp, Mercedes Machuca-Ostos, Guido de Roo, Ton N M Schumacher, Yik A Yeung, Kelly D Moynihan, Ivana M Djuretic, Daniela S Thommen
CD8-Targeted IL2 Unleashes Tumor-Specific Immunity in Human Cancer Tissue by Reviving the Dysfunctional T-cell Pool. Cancer discovery 14 (7) (2024)
Paulien Kaptein, Nadine Slingerland, Christina Metoikidou, Felix Prinz, Simone Brokamp, Mercedes Machuca-Ostos, Guido de Roo, Ton N M Schumacher, Yik A Yeung, Kelly D Moynihan, Ivana M Djuretic, Daniela S Thommen
CD8-Targeted IL2 Unleashes Tumor-Specific Immunity in Human Cancer Tissue by Reviving the Dysfunctional T-cell Pool. Cancer discovery 14 (7) (2024)
Karlijn Hummelink, Renaud Tissier, Linda J W Bosch, Oscar Krijgsman, Michel van den Heuvel, Willemijn S M E Theelen, Diane Damotte, Francois Goldwasser, Karen Leroy, Egbert F Smit, Gerrit A Meijer, Daniela S Thommen, Kim Monkhorst
A dysfunctional T cell gene signature for predicting non-response to PD-1 blockade in non-small cell lung cancer that is suitable for routine clinical diagnostics. Clinical cancer research : an official journal of the American Association for Cancer Research (2023)
Marcel Philipp Trefny, Nicole Kirchhammer, Priska Auf der Maur, Marina Natoli, Dominic Schmid, Markus Germann, Laura Fernandez Rodriguez, Petra Herzig, Jonas Lötscher, Maryam Akrami, Jane C Stinchcombe, Michal A Stanczak, Andreas Zingg, Melanie Buchi, Julien Roux, Romina Marone, Leyla Don, Didier Lardinois, Mark Wiese, Lukas T Jeker, Mohamed Bentires-Alj, Jérémie Rossy, Daniela S Thommen, Gillian M Griffiths, Heinz Läubli, Christoph Hess, Alfred Zippelius
Deletion of SNX9 alleviates CD8 T cell exhaustion for effective cellular cancer immunotherapy. Nature communications 14 (1) (2023)
Renata Varaljai, Lisa Zimmer, Yahya Al-Matary, Paulien Kaptein, Lea J Albrecht, Batool Shannan, Jan C Brase, Daniel Gusenleitner, Teresa Amaral, Nina Wyss, Jochen Utikal, Lukas Flatz, Florian Rambow, Hans Christian Reinhardt, Jenny Dick, Daniel R Engel, Susanne Horn, Selma Ugurel, Wiebke Sondermann, Elisabeth Livingstone, Antje Sucker, Annette Paschen, Fang Zhao, Jan M Placke, Jasmin M Klose, Wolfgang P Fendler, Daniela S Thommen, Iris Helfrich, Dirk Schadendorf, Alexander Roesch
Author Correction: Interleukin 17 signaling supports clinical benefit of dual CTLA-4 and PD-1 checkpoint inhibition in melanoma. Nature cancer (2023)
Anne M van der Leun, Joleen J H Traets, Joris L Vos, Joris B W Elbers, Sanne Patiwael, Xiaohang Qiao, Mercedes Machuca-Ostos, Daniela S Thommen, John B A G Haanen, Ton N M Schumacher, Charlotte L Zuur
Dual immune checkpoint blockade induces analogous alterations in the dysfunctional CD8+ T cell and activated Treg compartment. Cancer discovery (2023)
Marcel Philipp Trefny, Nicole Kirchhammer, Priska Auf der Maur, Marina Natoli, Dominic Schmid, Markus Germann, Laura Fernandez Rodriguez, Petra Herzig, Jonas Lötscher, Maryam Akrami, Jane C Stinchcombe, Michal A Stanczak, Andreas Zingg, Melanie Buchi, Julien Roux, Romina Marone, Leyla Don, Didier Lardinois, Mark Wiese, Lukas T Jeker, Mohamed Bentires-Alj, Jérémie Rossy, Daniela S Thommen, Gillian M Griffiths, Heinz Läubli, Christoph Hess, Alfred Zippelius
Deletion of SNX9 alleviates CD8 T cell exhaustion for effective cellular cancer immunotherapy. Nature communications 14 (1) (2023)
Marcel Philipp Trefny, Nicole Kirchhammer, Priska Auf der Maur, Marina Natoli, Dominic Schmid, Markus Germann, Laura Fernandez Rodriguez, Petra Herzig, Jonas Lötscher, Maryam Akrami, Jane C Stinchcombe, Michal A Stanczak, Andreas Zingg, Melanie Buchi, Julien Roux, Romina Marone, Leyla Don, Didier Lardinois, Mark Wiese, Lukas T Jeker, Mohamed Bentires-Alj, Jérémie Rossy, Daniela S Thommen, Gillian M Griffiths, Heinz Läubli, Christoph Hess, Alfred Zippelius
Deletion of SNX9 alleviates CD8 T cell exhaustion for effective cellular cancer immunotherapy. Nature communications 14 (1) (2023)
Renata Varaljai, Lisa Zimmer, Yahya Al-Matary, Paulien Kaptein, Lea J Albrecht, Batool Shannan, Jan C Brase, Daniel Gusenleitner, Teresa Amaral, Nina Wyss, Jochen Utikal, Lukas Flatz, Florian Rambow, Hans Christian Reinhardt, Jenny Dick, Daniel R Engel, Susanne Horn, Selma Ugurel, Wiebke Sondermann, Elisabeth Livingstone, Antje Sucker, Annette Paschen, Fang Zhao, Jan M Placke, Jasmin M Klose, Wolfgang P Fendler, Daniela S Thommen, Iris Helfrich, Dirk Schadendorf, Alexander Roesch
Interleukin 17 signaling supports clinical benefit of dual CTLA-4 and PD-1 checkpoint inhibition in melanoma. Nature cancer (2023)
Marcel Philipp Trefny, Nicole Kirchhammer, Priska Auf der Maur, Marina Natoli, Dominic Schmid, Markus Germann, Laura Fernandez Rodriguez, Petra Herzig, Jonas Lötscher, Maryam Akrami, Jane C Stinchcombe, Michal A Stanczak, Andreas Zingg, Melanie Buchi, Julien Roux, Romina Marone, Leyla Don, Didier Lardinois, Mark Wiese, Lukas T Jeker, Mohamed Bentires-Alj, Jérémie Rossy, Daniela S Thommen, Gillian M Griffiths, Heinz Läubli, Christoph Hess, Alfred Zippelius
Deletion of SNX9 alleviates CD8 T cell exhaustion for effective cellular cancer immunotherapy. Nature communications 14 (1) (2023)
Marcel Philipp Trefny, Nicole Kirchhammer, Priska Auf der Maur, Marina Natoli, Dominic Schmid, Markus Germann, Laura Fernandez Rodriguez, Petra Herzig, Jonas Lötscher, Maryam Akrami, Jane C Stinchcombe, Michal A Stanczak, Andreas Zingg, Melanie Buchi, Julien Roux, Romina Marone, Leyla Don, Didier Lardinois, Mark Wiese, Lukas T Jeker, Mohamed Bentires-Alj, Jérémie Rossy, Daniela S Thommen, Gillian M Griffiths, Heinz Läubli, Christoph Hess, Alfred Zippelius
Deletion of SNX9 alleviates CD8 T cell exhaustion for effective cellular cancer immunotherapy. Nature communications 14 (1) (2023)
Marcel Philipp Trefny, Nicole Kirchhammer, Priska Auf der Maur, Marina Natoli, Dominic Schmid, Markus Germann, Laura Fernandez Rodriguez, Petra Herzig, Jonas Lötscher, Maryam Akrami, Jane C Stinchcombe, Michal A Stanczak, Andreas Zingg, Melanie Buchi, Julien Roux, Romina Marone, Leyla Don, Didier Lardinois, Mark Wiese, Lukas T Jeker, Mohamed Bentires-Alj, Jérémie Rossy, Daniela S Thommen, Gillian M Griffiths, Heinz Läubli, Christoph Hess, Alfred Zippelius
Deletion of SNX9 alleviates CD8 T cell exhaustion for effective cellular cancer immunotherapy. Nature communications 14 (1) (2023)
Ton N M Schumacher, Daniela S Thommen
Tertiary lymphoid structures in cancer. Science (New York, N.Y.) 375 (6576) (2022)
Paulien Kaptein, Daniela S Thommen
Keeping track of the T cells that matter. Nature cancer 3 (9) (2022)
Daniela S Thommen
Tumour avatars to model patients' responses to immunotherapy. Nature reviews. Cancer 22 (12) (2022)
Karlijn Hummelink, Vincent van den Noort, Mirte Muller, Robert D Schouten, Ferry Lalezari, Dennis Peters, Willemijn S M E Theelen, Viktor Hendrik Koelzer, Kirsten D Mertz, Alfred Zippelius, Michel van den Heuvel, Annegien Broeks, John B A G Haanen, Ton N M Schumacher, Gerrit A Meijer, Egbert F Smit, Kim Monkhorst, Daniela S Thommen
PD-1T TILs as a Predictive Biomarker for Clinical Benefit to PD-1 Blockade in Patients with Advanced NSCLC. Clinical cancer research : an official journal of the American Association for Cancer Research 28 (22) (2022)
Paulien Kaptein, Célia Jacoberger Foissac, Petros Dimitriadis, Paula Voabil, Marjolein de Bruijn, Simone Brokamp, Irene Reijers, Judith M Versluis, Gahyathiri Nallan, Hannah Triscott, Elizabeth McDonald, Joshua Tay, Georgina V Long, Christian U Blank, Daniela S Thommen, Michele W L Teng
Addition of interleukin-2 overcomes resistance to neoadjuvant CTLA4 and PD1 blockade in ex vivo patient tumors. Science translational medicine 14 (642) (2022)
Nicole Kirchhammer, Marcel Philipp Trefny, Marina Natoli, Dominik Brücher, Sheena N Smith, Franziska Werner, Victoria Koch, David Schreiner, Ewelina Magdalena Bartoszek, Mélanie Buchi, Markus Schmid, Daniel Breu, K Patricia Hartmann, Polina Zaytseva, Daniela S Thommen, Heinz Laubli, Jan Philipp Böttcher, Michal A Stanczak, Abhishek S Kashyap, Andreas Plückthun, Alfred Zippelius
NK cells with tissue-resident traits shape response to immunotherapy by inducing adaptive antitumor immunity. Science translational medicine 14 (653) (2022)
Paula Voabil, Marjolein de Bruijn, Lisanne M Roelofsen, Sanne H Hendriks, Simone Brokamp, Marlous van den Braber, Annegien Broeks, Joyce Sanders, Petra Herzig, Alfred Zippelius, Christian U Blank, Koen J Hartemink, Kim Monkhorst, John B A G Haanen, Ton N M Schumacher, Daniela S Thommen
An ex vivo tumor fragment platform to dissect response to PD-1 blockade in cancer. Nature medicine 27 (7) (2021)
Judith M Versluis, Daniela S Thommen, Christian U Blank
Rationalizing the pathway to personalized neoadjuvant immunotherapy: the Lombard Street Approach. Journal for immunotherapy of cancer 8 (2) (2021)
Victoria S Pelly, Agrin Moeini, Lisanne M Roelofsen, Eduardo Bonavita, Charlotte R Bell, Colin Hutton, Adrian Blanco-Gomez, Antonia Banyard, Christian P Bromley, Eimear Flanagan, Shih-Chieh Chiang, Claus Jorgensen, Ton N M Schumacher, Daniela S Thommen, Santiago Zelenay
Anti-Inflammatory Drugs Remodel the Tumor Immune Environment to Enhance Immune Checkpoint Blockade Efficacy. Cancer discovery 11 (10) (2021)
Anne M van der Leun, Mirjam E Hoekstra, Luuk Reinalda, Colinda L G J Scheele, Mireille Toebes, Michel J van de Graaff, Linda Y Y Chen, Hanjie Li, Akhiad Bercovich, Yaniv Lubling, Eyal David, Daniela S Thommen, Amos Tanay, Jacco van Rheenen, Ido Amit, Sander Izaäk van Kasteren, Ton N M Schumacher
Single-cell analysis of regions of interest (SCARI) using a photosensitive tag. Nature chemical biology 17 (11) (2021)
Elise Alspach, Ryan D Chow, Shadhmer Demehri, Jennifer L Guerriero, Shashi Gujar, Felix J Hartmann, Beth A Helmink, William H Hudson, Won Jin Ho, Leyuan Ma, Barbara B Maier, Vivien I Maltez, Brian C Miller, Amy E Moran, Erin M Parry, Padmini S Pillai, Sarwish Rafiq, Miguel Reina-Campos, Pamela C Rosato, Nils-Petter Rudqvist, Megan K Ruhland, Idit Sagiv-Barfi, Avinash Das Sahu, Robert M Samstein, Christian M Schürch, Debattama R Sen, Daniela S Thommen, Yochai Wolf, Roberta Zappasodi
Supporting the Next Generation of Scientists to Lead Cancer Immunology Research. Cancer immunology research 9 (11) (2021)
Anne M van der Leun, Daniela S Thommen, Ton N M Schumacher
CD8+ T cell states in human cancer: insights from single-cell analysis. Nature reviews. Cancer 20 (4) (2020)
Marcel Philipp Trefny, Sacha I Rothschild, Franziska Uhlenbrock, Dietmar Rieder, Benjamin Kasenda, Michal A Stanczak, Fiamma Berner, Abhishek S Kashyap, Monika Kaiser, Petra Herzig, Severin Poechtrager, Daniela S Thommen, Florian Geier, Spasenija Savic, Philip Jermann, Ilaria Alborelli, Stefan Schaub, Frank Stenner, Martin Früh, Zlatko Trajanoski, Lukas Flatz, Kirsten D Mertz, Alfred Zippelius, Heinz Laubli
A Variant of a Killer Cell Immunoglobulin-like Receptor Is Associated with Resistance to PD-1 Blockade in Lung Cancer. Clinical cancer research : an official journal of the American Association for Cancer Research 25 (10) (2019)
Sarah Dimeloe, Patrick Gubser, Jordan Loeliger, Corina Frick, Leyla Develioglu, Marco Fischer, Florian Marquardsen, Glenn R Bantug, Daniela S Thommen, Yannic Lecoultre, Alfred Zippelius, Anja Langenkamp, Christoph Hess
Tumor-derived TGF-β inhibits mitochondrial respiration to suppress IFN-γ production by human CD4+ T cells. Science signaling 12 (599) (2019)
Daniela S Thommen, Viktor H Koelzer, Petra Herzig, Andreas Roller, Marcel Philipp Trefny, Sarah Dimeloe, Anna Kiialainen, Jonathan Hanhart, Catherine Schill, Christoph Hess, Spasenija Savic Prince, Mark Wiese, Didier Lardinois, Ping-Chih Ho, Christiane Neumann, Vaios Karanikas, Kirsten D Mertz, Ton N Schumacher, Alfred Zippelius
A transcriptionally and functionally distinct PD-1+ CD8+ T cell pool with predictive potential in non-small-cell lung cancer treated with PD-1 blockade. Nature medicine 24 (7) (2018)