Differences in Gene Expression of Endogenous Opioid Peptide Precursor, Cannabinoid 1 and 2 Receptors and Interleukin Beta in Peripheral Blood Mononuclear Cells of Patients With Refractory Failed Back Surgery Syndrome Treated With Spinal Cord Stimulation: Markers of Therapeutic Outcomes?
José Antonio De AndrésFrancisco Navarrete-RuedaGustavo FabregatMaria Salud García-GutiérrezVincente Monsalve-DolzAnushik HarutyunyanAna Mínguez-MartíRaquel Rodriguez-LopezJorge ManzanaresPublished in: Neuromodulation : journal of the International Neuromodulation Society (2020)
Previously unknown effects of SCS on levels of PBMCs biomarkers are demonstrated. The findings of our research suggest a potential for useful integration of genome analysis and lymphocyte expression in the daily practice of neurostimulation for pain management and represent a novel road map in the light of the important questions that remain unanswered.
Keyphrases
- pain management
- gene expression
- spinal cord
- chronic pain
- minimally invasive
- poor prognosis
- primary care
- healthcare
- coronary artery bypass
- dna methylation
- spinal cord injury
- physical activity
- peripheral blood
- type diabetes
- quality improvement
- genome wide
- binding protein
- surgical site infection
- metabolic syndrome
- coronary artery disease
- skeletal muscle
- high density
- human health
- glycemic control