H-Ras gene takes part to the host immune response to COVID-19.
Salvatore SciacchitanoAndrea SacconiClaudia De VitisGiovanni BlandinoGiulia PiaggioValentina SalvatiChristian NapoliPaolo MarchettiBeatrice Salimbeni TaurelliFlaminia ColuzziMonica RoccoAndrea VecchionePaolo AnibaldiAdriano MarcolongoGennaro CilibertoRita ManciniCarlo CapalboPublished in: Cell death discovery (2021)
Ras gene family members play a relevant role in cancer, especially when they are mutated. However, they may play additional roles in other conditions beside cancer. We performed gene expression analysis using the NanoString PanCancer IO 360 panel in the peripheral blood mononuclear cell (PBMC) of six COVID-19 patients and we found that H-Ras gene was significantly upregulated, while both K-Ras and N-Ras genes were downregulated. In particular, H-Ras gene upregulation was more evident in COVID-19 patients with a more severe disease. We compared our results with those obtained by analyzing two different and independent datasets, including a total of 53 COVID-19 patients, in which the gene expression analysis was performed using the Immunology_V2 panel. Comparative analysis of the H-Ras gene expression in these patients confirmed our preliminary results. In both of them, in fact, we were able to confirm the upregulation of the expression of the H-Ras gene. The exact role of this specific upregulation of the H-Ras gene in response to SARS-CoV-2 infection and its possible role in cancer still remains to be elucidated. In conclusion, H-Ras gene participates to the host immune response to SARS-CoV-2 virus infection, especially in patients affected by the most severe form of the COVID-19.
Keyphrases
- sars cov
- wild type
- genome wide identification
- genome wide
- gene expression
- copy number
- coronavirus disease
- end stage renal disease
- immune response
- poor prognosis
- peripheral blood
- dna methylation
- cell proliferation
- respiratory syndrome coronavirus
- newly diagnosed
- signaling pathway
- ejection fraction
- peritoneal dialysis
- squamous cell carcinoma
- early onset
- chronic kidney disease
- transcription factor
- young adults
- toll like receptor
- squamous cell
- binding protein
- childhood cancer