Epidermal growth factor upregulates expression of MUC5AC via TMEM16A, in chronic rhinosinusitis with nasal polyps.

Jian JiaoTao ZhangYu ZhangJingyun LiMin WangMing WangYing LiXiangdong WangLuo Zhang

Published in: Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology (2020)

This study demonstrated that EGF upregulates the expression of MUC5AC in HNECs from CRSwNP patients. Furthermore, the EGF-mediated regulation of MUC5AC expression is likely to involve a PI3K-TMEM16A signalling pathway in CRSwNP.

Keyphrases

growth factor
chronic rhinosinusitis
poor prognosis
end stage renal disease
ejection fraction
binding protein
chronic kidney disease
long non coding rna
peritoneal dialysis