Cognitive, creative, functional, and clinical symptom improvements in schizophrenia after an integrative cognitive remediation program: a randomized controlled trial.
Agurne SampedroJavier PeñaPedro M SanchezNaroa Ibarretxe-BilbaoAinara Gómez-GastiasoroNagore Iriarte-YollerCristóbal PavónMikel Tous-EspelosinNatalia OjedaPublished in: NPJ schizophrenia (2021)
This study analyzed the effectiveness of an integrative cognitive remediation program (REHACOP) in improving neurocognition, social cognition, creativity, functional outcome, and clinical symptoms in patients with schizophrenia. In addition, possible mediators predicting improvement in functional outcomes were explored. The program combined cognitive remediation with social cognitive training and social and functional skill training over 20 weeks. The sample included 94 patients, 47 in the REHACOP group and 47 in the active control group (occupational activities). Significant differences were found between the two groups in change scores of processing speed, working memory, verbal memory (VM), inhibition, theory of mind, emotion processing (EP), figural creative strengths, functional competence, disorganization, excitement, and primary negative symptoms. A mediational analysis revealed that changes in VM, inhibition, and EP partially explained the effect of cognitive remediation on functional competence improvement. This study provides initial evidence of the effect of integrative cognitive remediation on primary negative symptoms and creativity.
Keyphrases
- working memory
- healthcare
- randomized controlled trial
- mental health
- end stage renal disease
- chronic kidney disease
- autism spectrum disorder
- bipolar disorder
- attention deficit hyperactivity disorder
- depressive symptoms
- newly diagnosed
- transcranial direct current stimulation
- virtual reality
- patient reported outcomes
- sleep quality